This website allows you to estimate the most probable macromolecular targets of a small molecule, assumed as bioactive. The prediction is founded on a combination of 2D and 3D similarity with a library of 37 0'000 known actives on more than 3000 proteins from three different species.

The webtool is described in detail here: SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules, Nucl. Acids Res. (2019). For technical information about the prediction algorithm, you can refer to: Shaping the interaction landscape of bioactive molecules, Bioinformatics (2013) 29:3073-3079. Developed and maintained by the Molecular Modeling Group of the SIB | Swiss Institute of Bioinformatics.


SwissTargetPrediction is provided free-of-charge in the hope that it will be useful.

The SIB will not look queries from users, nor share them with a third party.
However, we make no guarantees about data confidentiality on this public service website.

We make no representation or warranty regarding results obtained from using any information provided through this server.

We bear no responsibility for any incidental or consequential damages or direct or indirect damages that result from the use of results, data or information, which have been provided through this server.